Pradobolognani and mauro muszkat download pdf 49 kb. Kleinelevin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Kleine levin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main. Kleine levin syndrome foundation genetic and rare diseases. Several treatments have been tried and recently lithium has been proposed for a prophylactic use in single cases. Kleinelevin syndrome is a rare neurological condition with both somatic and psychiatric symptoms.
Many patients also experience hyperphagia, hypersexuality and other symptoms. Table 1 diagnostic criteria for kleinelevin syndrome as defined by. You can download your own copy here kleine levin syndrome kls. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. The epub format uses ebook readers, which have several ease of reading. Imaging diagnostics refers to brain mri kleinelevin syndrome and other inherited sleep disorders inclusion criteria 29583 recurrent hypersomnia. In the light of this finding the autonomy of the syndrome seems questionable, since it differs only. Pharmacological treatment for kleinelevin syndrome.
Kls support uk helping families affected by kleinelevin. Nature and science of sleep dovepress kls foundation. Kleinelevin syndrome kls is a rare disorder which affects mainly adolescents. All books are in clear copy here, and all files are secure so dont worry about it. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. In a large cohort of 108 patients diagnosed with kleine levin syndrome, 25% had a complicated birth history and 15% had some degree of developmental delay. Kleine levin hibernation syndrome, familial kleine levin syndrome, familial hibernation syndrome. It is rare for patients over the age of 30 years to present with their first. Our patient presented successive episodes of selflimited hypersomnia, with no significant findings in any of the complementary tests performed during admission. Kls is a rare disorder characterised by recurrent bouts of excessive sleep associated with reduced understanding of. Kleine levin syndrome kls is characterized by recurrent episodes of hypersomnia, cognitive and mood disturbances, compulsive hyperphagia, and behavioral changes with frequent hypersexuality and signs of dysautonomia. Focal generalised status epilepticus myoclonic epilepsy. Kleinelevin hibernation syndrome, familial kleinelevin syndrome, familial hibernation syndrome.
Mignot1,2 1stanford university center for narcolepsy, 2howard hughes medical institute, palo alto, ca, 3kleinelevin. Kleinelevin syndrome kleinelevin syndrome treatment. Affected individuals may sleep for up to 20 hours per day during an episode. The kleinelevin syndrome effects of treatment with. The diagnostic characteristics are episodic hypersomnia, altered mental state, cognitive impairment, hallucinations, delusions, hyperphagia, and hypersexual behavior during episodes. Kleinelevin syndrome is rare sleep disorder characterized by episodic hypersomnia, cognitive dysfunction, psychiatric and behavioral disturbances. This site is like a library, you could find million book here by using search box in the. Kleinelevin syndrome kls is a rare disorder which mainly affects adolescent men. Kleine levin syndrome is a rare sleep disorder that mainly affects adolescents and is characterised by relapsingremitting episodes of severe hypersomnia, cognitive impairment, apathy, derealisation, and psychiatric and behavioural disturbances.
Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition. Wed like to understand how you use our websites in order to improve them. Insomnia hypersomnia sleep apnea obstructive congenital central hypoventilation syndrome narcolepsy cataplexy kleinelevin circadian rhythm sleep disorder advanced sleep phase disorder delayed fovilpe phase disorder nonhour sleepwake disorder jet lag. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Just over half of patients have hyperphagia, are hypersexual mainly boys, or have depressed mood. Normalpressure hydrocephalus nph, also called communicating hydrocephalus citation needed and malresorptive hydrocephalus, is a condition in which excess cerebrospinal fluid csf occurs in the ventricles, and with normal or slightly elevated cerebrospinal fluid pressure. Kleinelevin syndrome neurologia english edition elsevier. Diagnosis, disease course, and management of patients with. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting.
Kleinelevin syndrome is a rare disease whose diagnosis is based on clinical symptoms. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. Jul 10, 2017 kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. If patients do experience psychotic symptoms such as delusions or hallucinations, they are shortlived and parallel the duration of the. For language access assistance, contact the ncats public information officer. The eponym kleinelevin syndrome as defined above was coined by critchley and hoffman in 1942.
Hipotesis inmunogenetica find, read and cite all the research you need on researchgate. If i had any control what so ever on that, do you think any kls patient would be. Therapeutic and diagnostic studies have the lowest evidence level. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Usefulness of brain spect imaging in the study of recurrent.
Kleinelevin syndrome kls is characterized by recurrent episodes of hypersomnia, cognitive and mood disturbances, compulsive hyperphagia, and behavioral changes with frequent hypersexuality and signs of dysautonomia. Oliveira mm, conti c, saconato h, fernandes do prado g. The disorder strikes adolescents primarily but can occur in younger children and adults. Pdf kleinelevin syndrome kls is the commonest recurrent sleep disorder with a prevalence of 12 per million population. Kleinelevin syndrome kls is a rare disorder characterised, most notably, by periodic episodes of hypersomnolence and hyperphagia. If you have problems viewing pdf files, download the latest version of adobe reader. These episodes usually last for a few days to a few weeks. Between neurology and psychiatry, a difficult preliminary diagnosis. Kleine levin syndrome genetic and rare diseases information. Child psychiatry, childrens hospital, rue du morvan vandoeuvreles nancy. Most of the published studies have included only small numbers of patients. Kleine levin syndrome is rare, affecting an estimated 15 per million individuals. Recurrent episodes of excessive daytime sleepiness lasting for 2 days4 weeks episodes recur at least once per year alertness, cognitive function and behavior are normal between episodes hypersomnia and at least 1.
Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Citescore values are based on citation counts in a given year e. Kleinelevin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Symptoms may last for days to weeks, include excessive food intake, lack of energy, disorientation, irritability, and sensitivity to noise. Kleine levin syndrome kleine levin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Kleinelevin syndrome is a rare sleep disorder that mainly affects adolescents and is characterised by relapsingremitting episodes of severe hypersomnia, cognitive impairment, apathy, derealisation, and psychiatric and behavioural disturbances. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Periods of extreme somnolence alternate with megaphagia, psychomental changes and behavioural symptoms. As the fluid builds up, it causes the ventricles to enlarge and the pressure inside the head to increase, compressing. A case of a 19yearold man with a oneyear history of attacks of hypersomnia lasting several hours or days fitted the description of the kleinelevincritchley sindrome. Welcome to kls support uk we are a small charity offering help and support to those affected by kleinelevin syndrome also known as kleine levin syndrome or kls.
This study is a retrospective study including 15 kls patients of the past 19 years. First ct findings in the kleinelevincritchley syndrome. Kleine levin syndrome is a rare disease whose diagnosis is based on clinical symptoms. These serious episodes alternate with periods without any symptoms. This was shared by a family living with kls, lucy wanted to raise awareness on rare disease day 2016 about what it is like to live with kleine levin syndrome and i wanted to share her words. Dec 04, 2016 videos sobre tratamentos naturais, doencas, emagrecimento, fitness, vida saudavel e bem estar.
671 550 1259 17 668 1618 161 1395 444 1568 224 278 1222 1388 1158 315 1 214 780 419 493 54 700 774 392 1562 1311 689 1058 217 1068 971 1291 1285 1469 1126 1044 75